The use of thiopurine (azathioprine and mercaptopurine) reduces the immune response to viruses, which is associated with an increased risk of opportunistic infections. There is limited evidence that they increase the risk of respiratory infections.
The risks and benefits should be considered, but most patients can continue on a stable dose. In patients in stable remission, elderly patients and in the presence of concomitant pathology, it is recommended to stop taking thiopurine.
During a pandemic, it is recommended to avoid starting thiopurine or increasing the dose, which will allow patients to avoid potential side effects.
If the patient is in contact with a COVID-19 person, temporary withdrawal of thiopurine for 2 weeks should be considered.
If a patient tests positive for SARS-CoV-2 and/or develops COVID-19, temporary discontinuation of thiopurine may be recommended until the patient clears the infection.
The criteria for assessing their own health by young people (25-44 years old - according to the WHO classification) were distributed as follows: almost half of the respondents, regardless of gender, rated their own health as "good"; every 4th of those surveyed - as "very good"; “Mediocre” health was noted by every fifth woman and every tenth person; almost the same was the proportion of respondents who rated their own health as “bad”; the level of subjective assessment of "excellent health" was observed in every tenth man, while in women it was absent.
Независимо от периода жизненного цикла, необходимо повышать самооценку здоровья путем оптимизации социальной среды, введения основ здорового образа жизни (в частности, разные формы самореализации, регулярные занятия физической культурой и спортом оптимальной интенсивности, фитнесс, йога и т.д.). Ведь неадекватная самооценка собственного здоровья может изменить поведение человека в негативную сторону, привести к здоровью разрушительных или девиантных форм поведения.
